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Canine Epileptoid Cramping Syndrome (CECS), also known as Spike's Disease, (also known as Border Terrier's disease) is a hereditary canine disease with similarities to canine epilepsy, and is often associated with Border Terriers. CECS is a recently recognized problem which is theorised as being a metabolic, neurological or muscle disorder,〔(Border Terrier CECS )〕 but the cause has not yet been identified.〔(CECS Info )〕 In 2015 a study came to the conclusion that: "Canine epileptoid cramping syndrome in Border Terrier's is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet."〔http://onlinelibrary.wiley.com/doi/10.1111/jvim.13643/full〕 ==History== In 1994 an later on Diana Plange, a German veterinarian and Border Terrier Breeder (Malepartus) received several phone calls from anxious Border Terrier owners whose dogs Ms. Plange had bred. They were observing epileptic-like problems in their dogs. However, many of the presentations did not fit the classic form of epilepsy. So after taking a further health survey, she decided to give up on her own breeding program and started working to find the cause of this condition, which was epileptoid in character. Ms. Plange arranged to have more than 100 Border Terriers examined thoroughly in her own surgery as well as in specialists' clinics. Many of the affected dogs showed abnormal liver function which resulted in much of the early focus implicating hepatic disorders as the cause of the newly discovered disease. However, after the number of symptomatic dogs with apparently normal livers increased, the concentration shifted to diet in early 1999, as through thorough investigation she found that the symptoms were responding to a nutritional change. It soon became clear that the condition must have a genetic (hereditary) background. Ms. Plange wrote some articles discussing this disorder which were placed on her web site and published in different European dog magazines, as well as some veterinary magazines. As a result, there were more responses from Border Terrier owners and some veterinarians who felt their dogs were exhibiting these symptoms, not only from Germany and other parts of Europe, but from all over the world as well. Samples of liver tissues, blood and urine were sent to several laboratories including the U.S. Thereupon, a world wide cooperation among interested scientist started, and quite a number of people were involved. It was Erica Jabroer-ter Lüün from the Netherlands who stepped in at an early stage of Mrs. Plange`s investigations and in an enormous effort not only built up what can easily be recognized as the best Border Terrier database worldwide, but together with Mrs. Plange, coordinated research at several European universities. Ms. Plange came to the U.S. Border Terrier list in early 1999 inquiring about the BT's in America and asking if any dogs had unusual epileptic-like symptoms, because a number of suspected carriers were imported from GB to the USA. Ms. Kris Blake contacted Ms. Plange and found that the symptoms of her dog ‘Breaker’ were identical to those of the dogs in Germany and that his pedigree contained dogs who also suffered from the disorder. Then, with Kris Blake struggling with this unusual medical problem in her dog, the problem became recognized in the United States, too. In 1996, Joke Miedema, a Dutch Border Terrier owner, acquired a puppy named Roughmoor Blue Spike (known as Spike). About a year later, the dog began exhibiting strange symptoms, starting with apparent absentness and occasional staggering. In 2000, Spike began exhibiting more severe symptoms including cramping and epileptic-like fits; tests performed at Utrecht University in 2002 were Prof Rothuizen already had examined Border Terriers from Germany, determined that the dog did not have epilepsy.〔(Spike's Disease )〕 By the end of 2001, Spike was having 2–3 epileptoid episodes per week. Owners of cramping dogs began to connect via Internet groups, including a support group started by Miedema; the condition came to be known in NL as "Spike's Disease." 〔( Spike's Disease )〕 In science it is customary for the person who first described a condition to also give it a name. So in the spring of 2003 Diana Plange decided to give the condition a descriptive name: Canine Epileptoid Cramping Syndrome. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Canine Epileptoid Cramping Syndrome」の詳細全文を読む スポンサード リンク
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